“It is a complex containing inosine and a salt of 4-acetamidobenzoic acid with N,N-dimethylamino-2-propanol in a molar ratio of 1:3.
The effectiveness of the complex is determined by the presence of inosine; the second component increases its availability to lymphocytes. Groprinosin blocks the reproduction of viral particles by damaging the genetic apparatus, stimulates the activity of macrophages, the proliferation of lymphocytes and the formation of cytokines.
Reduces the clinical manifestations of viral diseases, accelerates convalescence, and increases the body’s resistance.
When Groprinosin is prescribed as an auxiliary drug for infectious lesions of the mucous membranes and skin caused by the Herpes simplex virus, faster healing of the affected surface occurs than with traditional treatment. New blisters, swelling, erosions and relapses of the disease occur less frequently.
With timely use of the drug, the incidence of viral infections is reduced, the duration and severity of the disease is reduced.
Indications
Immunodeficiency conditions caused by viral infections in patients with normal and weakened immune systems, incl. diseases caused by Herpes simplex viruses types 1 and 2 (including genital herpes and herpes of other localizations); subacute sclerosing panencephalitis.
Contraindications
gout;
urolithiasis disease;
arrhythmia;
chronic renal failure;
children under 3 years of age (body weight up to 15-20 kg);
pregnancy;
lactation period (breastfeeding);
hypersensitivity to the components of the drug.
The drug should be prescribed with caution with xanthine oxidase inhibitors, diuretics, zidovudine, in acute renal failure.
Side effects
Side effects are defined as frequent (>1/100 and 1/1000 and
From the nervous system: often – headache, dizziness, fatigue, poor health; infrequently – nervousness, drowsiness, insomnia.
From the gastrointestinal tract: often – loss of appetite, nausea, vomiting, epigastric pain; infrequently – diarrhea, constipation.
From the hepatobiliary system: often – increased activity of liver enzymes, alkaline phosphatase.
From the skin and subcutaneous fat: often – itching, rash.
From the kidneys and urinary tract: infrequently – polyuria.
Allergic reactions: uncommon – maculopapular rash, urticaria, angioedema.
From the musculoskeletal system: often – joint pain, exacerbation of gout.
Other: often – increased blood urea nitrogen concentration.”
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