“Description
Complex pine syrup is a medicine whose active substances are: pine cetin extract, anise tincture and codeine phosphate. The product is intended for adults and adolescents over 12 years of age and has antitussive properties.
Composition
The active substances of the syrup are: pine extract (Pini extractum fluidum) DER 1:0.9-1.1 extractant: ethanol 96 (v/v), anise tincture (Anisi tinctura) DER 1:4.5-5, 5 extractant: ethanol 70% (v/v) and codeine phosphate (Codeini phosphas hemihydricus).
15 ml of syrup (1 tablespoon) contains 1283.1 mg of pine cetin extract, 194.4 mg of anise tincture, 9.72 mg of codeine phosphate.
The excipients are: calcium lactate pentahydrate, diluted phosphoric acid, sucrose, purified water.
15 ml of the product contains approximately 12 g of sucrose.
Dosage
Always use this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist.
The recommended dosage for adults is 15 ml of syrup, 3 times a day. Dosage for adolescents aged 12-18 is 10-15 ml three times a day. The medicine can be measured using the measuring cup included in the package.
Indications
The syrup is indicated for emergency use during tiring, dry cough occurring in the course of upper respiratory tract infections.
Contraindications
The drug should not be used in case of allergy to any of the ingredients, as well as in patients with bronchial asthma or a tendency to bronchospasm, with acute respiratory failure, addicted to opioid drugs, with chronic constipation and in people with a very rapid metabolism of CYP2D6.
Side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Side effects caused by complex pine syrup include: drowsiness, dizziness, pressure drops, decreased respiratory rate, bronchospasm, constipation, biliary colic, nausea, vomiting, difficulty urinating and dry mouth.
The mentioned ailments occur with unknown frequency.
Warnings and precautions
Codeine inhibits the cough reflex, therefore it is intended only for relieving dry cough – do not use in patients who expectorate secretions.
Particular caution should be exercised when administering the product to people addicted to opioid drugs and substances and taking drugs from the group of morphine agonists or antagonists.
Particular caution should also be exercised in patients with: central nervous system (CNS) depression, respiratory depression and chronic lung diseases, increased intracranial pressure or head injuries, biliary tract diseases, including gallstones, renal failure, inflammatory or intestinal diseases leading to obstruction and in the elderly.
The medicine contains ethanol (15 ml of syrup contains 1156.2 mg of 96% ethanol) – it is harmful to people with alcoholism. The product also contains sucrose (15 ml of syrup contains about 12 g of sugar) – it should not be administered to people with disorders related to fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency.
Anethole contained in anise tincture may cause allergic reactions.
Store the medicine at room temperature. Do not freeze.
Keep the medicine out of the sight and reach of children.
Taking other medicines
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
The medicine contains codeine. Due to the possibility of overdose, make sure that none of the medications you are taking at the same time contain this substance.
Complex pine syrup interacts with: benzodiazepines and barbituric acid derivatives, neuroleptics, clonidine, opioid drugs (codeine intensifies the depressant effect on the CNS), glutethimide (used with codeine it may cause a state of euphoria), MAO inhibitors (and within 14 days after their use). withdrawal), antihistamines, drugs that lower blood pressure, metoclopramide (codeine may cause a weakening of the effect on intestinal peristalsis).
Additionally, codeine may increase the depressant effect of other opioid drugs on the respiratory center and enhance the effect of ethanol.”
