“Compound:
Active substance: colchicine – 1 mg in each tablet;
Other components: Sugar, povidone, sodium starch glycolate, magnesium stearate, microcrystalline cellulose, dye E-124.
Colchicine is used for the short-term treatment of gout attacks.
Colchicine is also used to prevent recurrence of gout attacks. The concentration of uric acid in the blood is increased in gout. Excess uric acid in the blood can cause uric acid crystals to form and accumulate in and around joints. Colchicine inhibits the development of the inflammatory response.
How to take Colchicine?
Colchicine should be taken exactly as prescribed by your doctor
Adults:
Use for gout
Treatment of an acute attack of gout:
The recommended dose is 0.5 mg two to three times a day. Your doctor may decide to prescribe an additional 1 mg on the first day of treatment. Treatment should be stopped if complaints from the gastrointestinal tract occur or if there is no effect after 2-3 days.
You should not take more than 6 mg of colchicine during the course of treatment. You should not start a new course for at least 3 days after finishing your course of colchicine treatment.
Preventing a gout attack:
The recommended dose is 0.5 – 1 mg per day and should be taken in the evening. Your doctor will tell you how long your colchicine treatment will last.
If you have problems with the liver and kidneys
If you have impaired liver or kidney function, the recommended dose is 0.5 mg of colchicine per day and you should be closely monitored. If you have severe liver or kidney problems, do not take this medicine.
Children and teenagers:
The medicine should not be used to treat gout in children and adolescents.
Use in familial Mediterranean fever (periodic disease)
The recommended dose is 1 – 3 mg per day. The daily dose may be a single dose or divided into two doses per day (for doses greater than 1 mg/day).
If you do not feel improvement, your doctor may gradually increase your colchicine dose to a maximum of 3 mg per day. Each time you increase your colchicine dose, your doctor should monitor you closely for side effects.
Use in children and adolescents under 18 years of age:
For children with familial Mediterranean fever (recurrent illness), the recommended dosage depends on age.
Children under 5 years: 0.5 mg per day. Children from 5 to 10 years: 1 mg per day.
Children over 10 years of age: 1.5 mg per day.
In children with amyloid nephropathy, the dose may be increased to 2 mg per day.
Do not take Colchicine:
if you are allergic to colchicine or any other part of this drug
if you have a serious blood disorder
if you have serious kidney problems
if you have serious liver problems
during pregnancy
while breastfeeding
if you are a woman of childbearing age and are not using effective contraception while taking the drug
if you are on hemodialysis, as colchicine cannot be removed by dialysis or exchange transfusion
if you have renal or hepatic impairment and are taking P-gp inhibitors or strong CYP3A4 inhibitors”
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